Well, sure one can, but I tend to err on the side of "the more, the merrier."
Of course, one of my former bosses referred to me as "Too Many Commas Man".
A Comma Problem among Editors | Copyediting.com
I like commas, perhaps a little too much. I like the way they give me more control over readers’ pacing, forcing them mentally to pause when I want them to pause and go when I want them to go. I like how they can break a sentence into discrete chunks while showing how those chunks relate to one …
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Too many commas, man
I find myself using fewer commas these days. I'm pretty sure I had been overusing them.